Compound class:
Synthetic organic
Comment: 1R-11 is a synthetic lipoxin mimetic that exhibits anti-inflammatory activities via a mechanism which appears to be mediated by agonism of the ALX/FPR2 G protein-coupled receptor [1].
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References |
1. de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A et al.. (2019)
Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms). Eur J Med Chem, 162: 80-108. [PMID:30419493] |