Ligand id: 10102

Name: mizolastine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 70.05
Molecular weight 432.21
XLogP 5.36
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Benavides J, Schoemaker H, Dana C, Claustre Y, Delahaye M, Prouteau M, Manoury P, Allen J, Scatton B, Langer SZ et al.. (1995)
In vivo and in vitro interaction of the novel selective histamine H1 receptor antagonist mizolastine with H1 receptors in the rodent.
Arzneimittelforschung, 45 (5): 551-8. [PMID:7612054]
2. Coon T, Moree WJ, Li B, Yu J, Zamani-Kord S, Malany S, Santos MA, Hernandez LM, Petroski RE, Sun A et al.. (2009)
Brain-penetrating 2-aminobenzimidazole H(1)-antihistamines for the treatment of insomnia.
Bioorg. Med. Chem. Lett., 19 (15): 4380-4. [PMID:19553115]