abrezekimab   Click here for help

GtoPdb Ligand ID: 9806

Synonyms: CDP7766 | UCB-4144 | UCB4144 | VR-942
Immunopharmacology Ligand
Compound class: Antibody
Comment: Abrezekimab (UCB4144) is an anti-IL-13 agent that is in development as an anti-asthmatic agent. Peptide sequences submitted to the WHO for the INN abrezekimab, match sequences claimed in UCB Pharma patent US8691233, namely sequence IDs 35 and 27 of the preferred antibody named Ab652 in the patent submission [2]. This biologic has been designed as a high-affinity antibody fragment that suitable for inhalation, to provide a more rapid onset of action at lower doses than subcutaneous systemic administration [1]. Efficacy has been demonstrated in asthma.
Immunopharmacology Comments
UCB4144 is a novel dry-powder formulation for inhalation that contains a high-affinity neutralizing anti-human-IL-13 monoclonal antibody fragment developed for the treatment of severe uncontrolled Th2-driven asthma.
Immunopharmacology Disease
Disease X-Refs Comment References
Asthma Disease Ontology: DOID:2841
OMIM: 600807
Phase 1 clinical candidate for asthma- see NCT02473939