Compound class:
Synthetic organic
Comment: Compound 47 is one of the most potent and selective IKKα inhibitors described in [1]. It inhibits agonist-stimulated NF-κB signaling of the noncanonical pathway at much lower concentrations than the canonical pathway.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Immunopharmacology Comments |
Compound 47 represents a chemical tool suitable for dissecting the roles of IKKα and IKKβ in cellular signaling, and may be used to help validate IKKα specifically as a target in inflammatory diseases. |