Synonyms: AMD 3100 | AMD3100 | bicyclam JM-2987 | JM 3100 | Mozobil®
plerixafor is an approved drug (FDA (2008), EMA (2009))
Compound class:
Synthetic organic
Comment: Plerixafor (AMD3100) is an antagonist of the chemokine (C-X-C motif) receptor 4 (CXCR4) [6]. It acts as a stem cell mobiliser.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Multiple myeloma |
Disease Ontology:
DOID:9538 OMIM: 254500 |
Immunostimulant stem cell mobiliser used in autologous stem cell transplantation. | |
non-Hodgkin lymphoma |
Disease Ontology:
DOID:0060060 OMIM: 605027 |
Immunostimulant stem cell mobiliser used in autologous stem cell transplantation. |