ustekinumab   Click here for help

GtoPdb Ligand ID: 6885

Synonyms: CNTO-1275 | L04AC05 | Stelara® | TT-20
Approved drug Immunopharmacology Ligand
ustekinumab is an approved drug (FDA (2009), EMA (2009))
Compound class: Antibody
Comment: Ustekinumab suppresses the immunomodulatory actions of both IL-12 and IL-23 on T-cell sub-populations. It binds to the common p40 subunit (IL12B) shared by these cytokines.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

NameTrade nameCompanyClinical PhaseIndications
ustekinumab-auub; ABP 654WezlanaAmgenApproved (2023 FDA)As per reference agent; Interchangeable with reference agent
Immunopharmacology Disease
Disease X-Refs Comment References
Psoriasis Disease Ontology: DOID:8893
An anti-IL-12B therapy approved to treat psoriasis.
Psoriatic arthritis Disease Ontology: DOID:9008
An anti-IL-12B therapy approved to treat PsA.
Ulcerative colitis Disease Ontology: DOID:8577
OMIM: 266600
Orphanet: ORPHA771
FDA approved for the treatment of moderate-severe UC in October 2019. Results from Phase 3 clinical trial NCT02407236 showed that ustekinumab was more effective than placebo as measured by induction and maintainance of clinical remission. 2