Synonyms: IL-1ra | interleukin-1 receptor antagonist protein | IRAP
Compound class:
Endogenous peptide in human, mouse or rat
Comment: A recombinant, non-glycosylated version of this protein is marketed as rheumatoid arthritis drug anakinra.
Species: Human
|
Immunopharmacology Comments |
IL-1Ra is an IL-1 family cytokine. It is a functional antagonist for IL-1α and IL-1β. |
Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Deficiency of IL-1 receptor antagonist |
OMIM:
612852 Orphanet: ORPHA210115 |
DIRA is caused by mutations in the IL1RN gene that cause loss of function of IL-1RA protein. The condition is responsive to IL-1 blocking therapies such as anakinra, rilonacept, and canakinumab. | 1-2 |
Rheumatoid arthritis |
Disease Ontology:
DOID:7148 OMIM: 180300 |
A recombinant, non-glycosylated version of this protein is marketed as rheumatoid arthritis drug called Anakinra |