IFN-ω

Home
Ligands
IFN-ω (Human)

GtoPdb Ligand ID: 4970

Synonyms: interferon alpha-II-1 | interferon omega-1

Compound class: Endogenous peptide in human, mouse or rat

Comment: IFN-ω is a type I IFN. In humans, only one functional form has been characterised; however, several pseudogenes are described.

Species: Human

Summary
Biological activity
Structure
Immunopharmacology

Immunopharmacology Comments
IFN-ω is secreted by leukocytes at the site of viral infection or by tumors. Like other type I IFNs, IFN-ω binds the IFN-α/β receptor (IFNAR), a dimeric receptor that consists of protein chains encoded by the IFNAR1 and IFNAR2 genes, and induces expression of proteins containing ISRE or GAS transcription elements.

Immunopharmacology Comments

IFN-ω is secreted by leukocytes at the site of viral infection or by tumors. Like other type I IFNs, IFN-ω binds the IFN-α/β receptor (IFNAR), a dimeric receptor that consists of protein chains encoded by the IFNAR1 and IFNAR2 genes, and induces expression of proteins containing ISRE or GAS transcription elements.