Synonyms: Actimmune® | immune interferon | interferon gamma
IFN-γ is an approved drug (FDA (1999))
Compound class:
Endogenous peptide in human, mouse or rat
Comment: IFN-γ is a type II interferon. It is biologically active as a homodimer.
Species: Human
![]() View more information in the IUPHAR Pharmacology Education Project: interferon-gamma (ifn-γ) |
Immunopharmacology Comments |
IFN-γ is produced by Th1 cells. It binds the IFN-γ receptor (IFNGR), a dimeric receptor that consists of protein chains encoded by the IFNGR1 and IFNGR2 genes. IFN-γ induces expression of genes with gamma interferon activation site (GAS) elements. Innate lymphoid ILC1s release IFN-γ in inflamaed conditions |
Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Chronic granulomatous disease |
Disease Ontology:
DOID:3265 Orphanet: ORPHA379 |
Approved therapy for chronic granulomatous disease. |