CXCL12α   Click here for help

GtoPdb Ligand ID: 4358

Synonyms: CXCL12 α | SDF-1α | stromal cell-derived factor-1α
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CXCL12-1α and β were the first isoforms of this chemokine identified. Both proteins contain a signal peptide sequence that mediates their secretion via the canonical intracellular secretory pathway. CXCL12 participates in a variety of processes central to homeostasis and physiology, exerting its biological effects by binding to the chemokine receptors CXCR4 and CXCR7.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Immunopharmacology Comments
CXCL12 is involved in controlling the directional migration of leukocytes under normal and pathological conditions. Pharmacological inhibitors of the CXCL12-CXCR4/CXCR7 axis are being evaluated as novel anti-inflammatory agents [15]. There is evidence to suggest a role for CXCL12 and its receptors in cancer cell migration (metastasis) [5,8,10], and to indicate that disruption of the CXCL12-CXCR4 axis could be considered as a novel anti-HIV-1 mechanism [9].
Immunopaedia Case Studies Links
In the Red