Synonyms: humanized OKT3 | MGA031 | PRV-031 | teplizumab-mzwv | Tzield®
teplizumab is an approved drug (FDA (2022))
Compound class:
Antibody
Comment: Teplizumab is a humanized anti-CD3e monoclonal antibody that was originally developed as an immunomodulatory agent. Structurally it is a modified version of the mouse antibody muromonab-CD3 (mOKT3) that has been used to reverse steroid-resistant renal allograft rejection. Alterations in the OKT3 CH2 domain disrupt Fcγ receptor binding, and blocks antibody-mediated effector cells functions and cytokine release [5,7]. It was advanced to extended clinical evaluations for potential to protect pancreatic β-cells in newly diagnosed type 1 diabetes (T1D) patients [4,6], following evidence that it impaired expansion of alloreactive anti-β cell T cells [5], and that a single short course of teplizumab treatment could induce a long-lasting improvement in patients' C-peptide responses and clinical parameters (including preservation of insulin production) in the early stages of T1D [2-3].
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Immunopharmacology Comments |
Like other anti-CD3e agents, teplizumab has immunosuppressive activity. It was engineered to minimise the human anti-mouse antibody and "cytokine release syndrome" responses that are associated with its parent antibody muromonab-CD3. |
Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Diabetes mellitus, insulin-dependent; IDDM |
Disease Ontology:
DOID:9744 OMIM: 222100 |
Approved drug: Delays immune-mediated damage of pancreatic β cells and preserves insulin production in the early stages of T1DM. |