WRWWWW   Click here for help

GtoPdb Ligand ID: 1040

Synonyms: WRW4
Immunopharmacology Ligand
Compound class: Peptide or derivative
Comment: Selective FPR2 antagonist peptide.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Immunopharmacology Comments
FPR2 antagonists have shown potential cytoprotective activity, as protection against inflammation-associated oxidative stress [4]. In addition, formyl-peptide receptor agonists have been shown to target ALX/FPR2 inflammation resolution pathways that may be of therapeutic benefit in chronic neutrophilic inflammation [2].