AM-6120   Click here for help

GtoPdb Ligand ID: 10119

Synonyms: AM6120 | peptide 41 [PMID: 30346167]
Immunopharmacology Ligand
Comment: AM-6120 is a peptidic voltage-gated sodium channel blocker with the sequence Glu-[Pra1;Nle6;Ala12;5-BrW24;Glu28]JzTx-V(1-29), where JzTx-V is a sodium channel inhibitor isolated from tarantula venom [2]. JzTx-V inhibits NaV1.7 activity by interacting with the second voltage sensor domain of the NaV1.7 pore forming α-subunit and thereby holding the ion channel in a closed conformation, but its action is non-selective [1].
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Immunopharmacology Comments
Subcutaneously administered AM-6120 blocks histamine-induced pruritis in mice [2].