AM-6120 [Ligand Id: 10119] activity data from GtoPdb

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  • Nav1.4 in Human [GtoPdb: 581] [UniProtKB: P35499]
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  • Nav1.5 in Human [GtoPdb: 582] [UniProtKB: Q14524]
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  • Nav1.6 in Human [GtoPdb: 583] [UniProtKB: Q9UQD0]
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  • Nav1.7 in Human [GtoPdb: 584] [UniProtKB: Q15858]
  • Nav1.7 in Mouse [GtoPdb: 584] [UniProtKB: Q62205]
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  • Nav1.8 in Human [GtoPdb: 585] [UniProtKB: Q9Y5Y9]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Nav1.4 in Human [GtoPdb: 581] [UniProtKB: P35499]
GtoPdb Determined in a PatchXpress electrophysiology experiment using HEK293 cells stably expressing hNaV1.4. - 6.98 pIC50 104 nM IC50 J. Med. Chem. (2018) 61: 9500-9512 [PMID:30346167]
Nav1.5 in Human [GtoPdb: 582] [UniProtKB: Q14524]
GtoPdb Determined in a PatchXpress electrophysiology experiment using HEK293 cells stably expressing hNaV1.5. - 5.18 pIC50 6640 nM IC50 J. Med. Chem. (2018) 61: 9500-9512 [PMID:30346167]
Nav1.6 in Human [GtoPdb: 583] [UniProtKB: Q9UQD0]
GtoPdb Determined in a PatchXpress electrophysiology experiment using HEK293 cells stably expressing hNaV1.6. - 6.22 pIC50 604 nM IC50 J. Med. Chem. (2018) 61: 9500-9512 [PMID:30346167]
Nav1.7 in Human [GtoPdb: 584] [UniProtKB: Q15858]
GtoPdb Determined in a PatchXpress electrophysiology experiment using HEK293 cells stably expressing hNaV1.7. - 9.1 pIC50 0.8 nM IC50 J. Med. Chem. (2018) 61: 9500-9512 [PMID:30346167]
Nav1.7 in Mouse [GtoPdb: 584] [UniProtKB: Q62205]
GtoPdb Determined in a PatchXpress electrophysiology experiment using HEK293 cells stably expressing mNaV1.7. - 8.27 pIC50 5.4 nM IC50 J. Med. Chem. (2018) 61: 9500-9512 [PMID:30346167]
Nav1.8 in Human [GtoPdb: 585] [UniProtKB: Q9Y5Y9]
GtoPdb Determined in a PatchXpress electrophysiology experiment using HEK293 cells stably expressing hNaV1.8. - 6 pIC50 >1000 nM IC50 J. Med. Chem. (2018) 61: 9500-9512 [PMID:30346167]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.