Synonyms: compound 32J [WO2016201225A1] | LYC-55716 | LYC55716
Compound class:
Synthetic organic
Comment: Cintirorgon (LYC-55716) is a first-in-class, oral, selective RORγ agonist that is being developed by Lycera as a novel immuno-oncology agent. It is one of the chemical structures claimed in Lycera's patent WO2016201225A1 [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Immunopharmacology Comments |
RORγ agonists appear to modulate gene expression in such a way as to reprogramme immune cells and improve their function, and to decrease immunosuppressive mechanisms of immune cells. In sum, this action has been shown to decrease tumour growth and enhance survival in in vivo preclinical models of cancer. |