mometasone   Click here for help

GtoPdb Ligand ID: 9029

Synonyms: Elocon® (topical) | Nasonex®
Approved drug Immunopharmacology Ligand
mometasone is an approved drug (1987 (FDA))
Compound class: Synthetic organic
Comment: Mometasone is a corticosteroid anti-inflammatory drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 74.6
Molecular weight 426.14
XLogP 2.12
No. Lipinski's rules broken 0
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Canonical SMILES ClCC(=O)C1(O)C(C)CC2C1(C)CC(O)C1(C2CCC2=CC(=O)C=CC12C)Cl
Isomeric SMILES ClCC(=O)[C@@]1(O)[C@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl
InChI InChI=1S/C22H28Cl2O4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
No information available.
Summary of Clinical Use Click here for help
Mometasone is used intranasally in the management of asthma, allergic rhinitis and nasal polyposis, and topically for allergic skin disorders. Prescribed formulations contain mometasone furoate (PubChem CID 441336).

A fixed-dose combination of indacaterol/glycopyrrolate/mometasone furoate (QVM149, Enerzair® Breezhaler®) has completed Phase 3 evaluation as a once-daily therapy for uncontrolled asthma [1]. Results confirmed non-inferiority to twice-daily salmeterol/fluticasone high-dose + tiotropium, and using a medium-dose had comparable efficacy but at a corresponding lower steroid dose.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The antiinflammatory actions of corticosteroids are thought to involve inhibition of several pathways involved in resolution of inflammation, including inhibition of cytosolic phospholipase A2 (through activation of lipocortin-1 (annexin)) which controls the biosynthesis of pro-inflammatory prostaglandins and leukotrienes.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT03158311 Study to Compare QVM149 and Free Triple Combination of Salmeterol/Fluticasone + Tiotropium Phase 3 Interventional Novartis Based on results from this trial, this combination therapy is under regulatory review in multiple countries to gain clinical approval. 1
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