Compound class:
Synthetic organic
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No information available. |
Mechanism Of Action and Pharmacodynamic Effects |
PIP5K1A is responsible for the production of PIP2 (phosphatidylinositol 4,5-bisphosphate, PtdIns-4,5-P2) [2], which is subsequently converted to PIP3 (phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3), an activator of the AKT family of serine/threonine kinases [1,4]. Elevated AKT activity is frequently observed in human cancer cells. Inhibition of PIP5K1A would therefore be expected to reduce PIP2 levels and AKT activity, with potential anti-cancer effects. |