tralokinumab   Click here for help

GtoPdb Ligand ID: 8001

Synonyms: Adbry® | Adtralza® | BAK1.1 [2] | CAT-354 [2] | tralokinumab-ldrm
Approved drug Immunopharmacology Ligand
tralokinumab is an approved drug (EMA & FDA (2021))
Compound class: Antibody
Comment: Tralokinumab is a monoclonal antibody directed against interleukin 13 (IL-13), a cytokine secreted by T helper cells, and which is a central mediator of the physiological changes induced by allergic inflammatory reactions [4] Binding affinity of tralokinumab was optimised (aka affinity maturation) using an in vitro ribosome display technology [2].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
No information available.
Summary of Clinical Use Click here for help
Tralokinumab was investigated in clinical trials for efficacy in patienst with uncontrolled asthma, atopic dermatitis, and alopecia areata. Click here to link to ClinicalTrials.gov's listing of Phase 3 tralokinumab trials. In addition, Phase 2 trials evaluated tralokinumab as a treatment for idiopathic pulmonary fibrosis (IPF, NCT01629667 and NCT02036580). Business reports online indicate that AstraZeneca discontinued tralokinumab development for asthma as it showed no benefit over placebo in their STRATOS 2 and TROPOS late-stage asthma trials [1].
The EMA approved LEO Pharma's tralokinumab product Adtralza® in July 2021, as a treatment for severe atopic dermatitis that cannot be controlled by topical drugs. FDA approval for this indication followed at the end of 2021.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
IL-13 induces airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion in allergic lung disease such as asthma [3]. These changes contribute to airway obstruction. Tralokinumab was designed to neutralise circulating IL-13, thereby reducing disease symptoms.
External links Click here for help