resminostat   Click here for help

GtoPdb Ligand ID: 7502

Synonyms: 4SC-201 | BYK408740 | RAS2410
PDB Ligand
Compound class: Synthetic organic
Comment: Resminostat is an HDAC inhibitor with selectivity for HDACs 1, 3 and 6, with significantly lower affinity for HDAC8 [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 100.02
Molecular weight 349.11
XLogP 1.08
No. Lipinski's rules broken 0
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Canonical SMILES ONC(=O)C=Cc1ccn(c1)S(=O)(=O)c1ccc(cc1)CN(C)C
Isomeric SMILES ONC(=O)/C=C/c1ccn(c1)S(=O)(=O)c1ccc(cc1)CN(C)C
InChI InChI=1S/C16H19N3O4S/c1-18(2)11-13-3-6-15(7-4-13)24(22,23)19-10-9-14(12-19)5-8-16(20)17-21/h3-10,12,21H,11H2,1-2H3,(H,17,20)/b8-5+
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Summary of Clinical Use Click here for help
In 2011, the European Medicines Agency granted orphan designation to resminostat for the treatment of patients with Hodgkin's lymphoma. Click here to link to's full list of resminostat studies.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
In Hodgkin's lymphoma, resminostat swittches on genes which suppress the division and growth of the tumour cells, thereby leading to a reduction in the growth and division of the cancerous cells. Resminostat modulates the expression/activity of apoptotisis-associated proteins such as Bim, Bax, Bcl-xL, and caspases 3, 8 and 9 [1].