arformoterol   Click here for help

GtoPdb Ligand ID: 7479

Synonyms: Brovana® | YM-08316
Approved drug PDB Ligand Immunopharmacology Ligand
arformoterol is an approved drug (FDA (2006))
Compound class: Synthetic organic
Comment: Arformoterol is the active (R,R)-enantiomer of formoterol. The marketed product contains arformoterol tartrate (PubChem CID 9827062).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 9
Topological polar surface area 90.82
Molecular weight 344.17
XLogP 2.21
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O
Isomeric SMILES O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O
InChI InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)/t13-,19+/m1/s1
InChI Key BPZSYCZIITTYBL-YJYMSZOUSA-N
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Summary of Clinical Use Click here for help
Arformoterol is indicated for the treatment of chronic obstructive pulmonary disease (COPD) and asthma.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Arformoterol is a long acting inhalation β-adrenoceptor agonist. β2-agonists cause bronchodilation and improve breathing via relaxation of the smooth muscle of the airway .
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