meloxicam   Click here for help

GtoPdb Ligand ID: 7220

Synonyms: Mobic® | UHAC-62XX
Approved drug PDB Ligand Immunopharmacology Ligand
meloxicam is an approved drug (FDA (2000))
Compound class: Synthetic organic
Comment: Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic actions.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 139.71
Molecular weight 351.03
XLogP 2.02
No. Lipinski's rules broken 0
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Canonical SMILES Cc1cnc(s1)N=C(C1=C(O)c2ccccc2S(=O)(=O)N1C)O
Isomeric SMILES Cc1cnc(s1)N=C(C1=C(O)c2ccccc2S(=O)(=O)N1C)O
InChI InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)
No information available.
Summary of Clinical Use Click here for help
This drug is used to treat pain and inflammation associated with osteo- and rheumatoid arthritis.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
As with other NSAIDs, this drug reduces prostaglandin synthesis by reducing cyclooxegenase (COX) activity.
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