loratadine   Click here for help

GtoPdb Ligand ID: 7216

Synonyms: Claritin® | SCH-29851
Approved drug Immunopharmacology Ligand
loratadine is an approved drug (FDA (1993))
Compound class: Synthetic organic
Comment: Loratidine is an antihistamine; peripheral H1 receptor antagonist; antiallergic agent.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 42.43
Molecular weight 382.14
XLogP 3.82
No. Lipinski's rules broken 0
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Canonical SMILES CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1
Isomeric SMILES CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1
InChI InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
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Summary of Clinical Use Click here for help
Loratidine is used to relieve the symptoms of allergic rhinitis and chronic idiopathic urticaria.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Loratadine blocks the action of endogenous histamine at the histamine H1 receptor.
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