carphenazine   Click here for help

GtoPdb Ligand ID: 7140

Synonyms: Proketazine® | WY-2445
Approved drug
carphenazine is an approved drug
Compound class: Synthetic organic
Comment: Carphenazine is an antipsychotic drug. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation. The Electronic Medicines Compendium (eMC) lists buclizine only as an active ingredient in a multi-component, anti-migraine treatment alongside paracetamol and codeine.
Marketed formulations may contain carphenazine maleate (PubChem CID 20838085).
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 72.32
Molecular weight 425.21
XLogP 3.37
No. Lipinski's rules broken 0
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Canonical SMILES OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(=O)CC
Isomeric SMILES OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(=O)CC
InChI InChI=1S/C24H31N3O2S/c1-2-22(29)19-8-9-24-21(18-19)27(20-6-3-4-7-23(20)30-24)11-5-10-25-12-14-26(15-13-25)16-17-28/h3-4,6-9,18,28H,2,5,10-17H2,1H3
No information available.
Summary of Clinical Use Click here for help
Used within the hospital setting to treat patients with chronic schizophrenia.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Carphenazine blocks postsynaptic dopamine D1 and D2 receptors in the brain.