vinblastine   Click here for help

GtoPdb Ligand ID: 6851

Synonyms: 29060-LE | Velban® | Velbe® | vincaleucoblastin | vincaleukoblastine
Approved drug PDB Ligand
vinblastine is an approved drug (FDA (1965))
Compound class: Synthetic organic
Comment: A pan tubulin inhibitor that is a chemical analogue of vincristine (from Catharanthus roseus, also known as Vinca rosea). There is some ambiguity surrounding the exact stereochemistry of vinblastine. The chirality shown here corresponds to the PubChem CID provided on the Summary tab. However, bioactivity data for the compound is also listed against CID 241903, and some of the external resource links refer to this chiral specification or others. Marketed formulations contain vinblastine sulfate (PubChem CID 5388983).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 11
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 154.1
Molecular weight 810.42
XLogP 4.73
No. Lipinski's rules broken 1
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Canonical SMILES COc1cc2N(C)C3C4(c2cc1C1(CC2CN(CCc5c1[nH]c1c5cccc1)CC(C2)(O)CC)C(=O)OC)CCN1C4C(C(C3(O)C(=O)OC)OC(=O)C)(CC)C=CC1
Isomeric SMILES COc1cc2N(C)[C@@H]3[C@@]4(c2cc1[C@]1(C[C@H]2CN(CCc5c1[nH]c1c5cccc1)C[C@](C2)(O)CC)C(=O)OC)CCN1[C@H]4[C@@]([C@H]([C@]3(O)C(=O)OC)OC(=O)C)(CC)C=CC1
InChI InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
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Summary of Clinical Use Click here for help
Used to treat certain kinds of cancer, including Hodgkin's lymphoma, non-small cell lung cancer, breast cancer, head and neck cancer, and testicular cancer. It is also used to treat Langerhans cell histiocytosis.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Causes cell cycle arrest by inhibiting microtubule assembly.
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