bupranolol   Click here for help

GtoPdb Ligand ID: 550

Synonyms: Betadrenol® | BRN 2272923 | Ophtorenin® | SK&F 16805-A
Approved drug
bupranolol is an approved drug
Compound class: Synthetic organic
Comment: Bupranolol is a β-adrenoceptor antagonist (beta blocker) with a similar potency to propranolol.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 41.49
Molecular weight 271.13
XLogP 3.24
No. Lipinski's rules broken 0
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Canonical SMILES OC(COc1cc(C)ccc1Cl)CNC(C)(C)C
Isomeric SMILES OC(COc1cc(C)ccc1Cl)CNC(C)(C)C
InChI InChI=1S/C14H22ClNO2/c1-10-5-6-12(15)13(7-10)18-9-11(17)8-16-14(2,3)4/h5-7,11,16-17H,8-9H2,1-4H3
No information available.
Summary of Clinical Use Click here for help
Used in the treatment of hypertension and tachycardia and in the management of glaucoma. Bupranolol does not appear to have marketing approval in the US or EU, although individual countries may have approved use of this drug.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Bupranolol reduces resting heart rate, cardiac output, and blood pressure by inhibiting sympathetic stimulation arising from β1-adrenergic receptor activation in the heart.