TSH

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Ligands
TSH (Human)

GtoPdb Ligand ID: 3920

Synonyms: Thyrogen® | thyroid-stimulating hormone | thyrotropin

TSH is an approved drug (FDA (1953))

Compound class: Endogenous peptide in human, mouse or rat

Comment: The drug thyrotropin alfa is a peptide heterodimer consisting of an α and β subunit and mimics the endogenous peptide hormone.

Species: Human

View more information in the IUPHAR Pharmacology Education Project: tsh

Summary
Biological activity
Clinical data
Structure
Similar ligands
(Un)labelled forms

No information available.

No information available.

Summary of Clinical Use
Thyrotropin alfa is used to promote the uptake of iodine for more effective radioactive iodine ablation treatment of some thyroid cancers. May also be used as hormone replacement therapy.

Summary of Clinical Use

Thyrotropin alfa is used to promote the uptake of iodine for more effective radioactive iodine ablation treatment of some thyroid cancers. May also be used as hormone replacement therapy.

Mechanism Of Action and Pharmacodynamic Effects
Thyrotropin alfa binds to TSH receptors found on normal thyroid epithelial cells or on well-differentiated thyroid cancer tissue.

Mechanism Of Action and Pharmacodynamic Effects

Thyrotropin alfa binds to TSH receptors found on normal thyroid epithelial cells or on well-differentiated thyroid cancer tissue.