cabergoline   Click here for help

GtoPdb Ligand ID: 37

Synonyms: Cabaser® | Caberlin®
Approved drug
cabergoline is an approved drug (FDA (1996))
Comment: Cabergoline is an ergot-derived, long-acting dopamine receptor agonist (dopamine D2 receptor) and prolactin inhibitor.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 71.68
Molecular weight 451.29
XLogP 2.87
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES C=CCN1CC(CC2C1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C
Isomeric SMILES C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C
InChI InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1
InChI Key KORNTPPJEAJQIU-KJXAQDMKSA-N
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Summary of Clinical Use Click here for help
Cabergoline is used to treat hyperprolactinemic disorders and to manage symptoms of Parkinson's disease.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Cabergoline stimulation of dopamine D2 receptors in the nigrostriatal pathway leads to improvements in coordinated muscle activity in those with movement disorders. In lactotrophs, stimulation of dopamine D2 receptors causes inhibition of adenylyl cyclase and results in decreased prolaction secretion.
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