Ligand id: 3340

Name: montelukast

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 12
Topological polar surface area 95.72
Molecular weight 585.21
XLogP 7.89
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of asthma.
Mechanism Of Action and Pharmacodynamic Effects
Antagonises the action of leukotriene D4 at the CysLT1 receptor in the airway. This prevents airway edema, smooth muscle contraction and enhanced secretion of thick, viscous mucus.
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