mosunetuzumab   Click here for help

GtoPdb Ligand ID: 12298

Synonyms: BTCT4465A | CD20-TDB [7] | Lunsumio® | mosunetuzumab-axgb | RG-7828 | RO7030816
Approved drug
mosunetuzumab is an approved drug (EMA & FDA (2022))
Compound class: Antibody
Comment: Mosunetuzumab (BTCT4465A) is an anti-CD20(MS4A1)/CD3e bispecific antibody [7] that was developed by Roche/Genentech to eliminate CD20+ve B cell malignancies by recruiting and activating effector T cells [1,4-5].
No information available.
Summary of Clinical Use Click here for help
Mosunetuzumab (BTCT4465A) was approved by both the EMA and FDA in 2022 [6]. It is indicated as a treatment for relapsed or refractory follicular lymphoma.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT04712097 A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide in Patients With Follicular Lymphoma After at Least One Line of Systemic Therapy Phase 3 Interventional Hoffmann-La Roche 3
NCT02500407 A Safety, Efficacy and Pharmacokinetic Study of BTCT4465A (Mosunetuzumab) as a Single Agent and Combined With Atezolizumab in Non-Hodgkin's Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL) Phase 1/Phase 2 Interventional Genentech, Inc. 2