BT-11   Click here for help

GtoPdb Ligand ID: 10363

Synonyms: analogue 7 [PMID: 27933891] | BT11 | Example 1 [US9556146B2]
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: BT-11 is an orally active anti-inflammatory agent that operates as a LANCL2 pathway activator [3]. It is being developed by Landos Biopharma, and is Example 1 as claimed in patent US9556146B2 [1]. The physicochemical properties of BT-11 suggest that it may offer a drug with minimal systemic distribution, and be more suited to local action in the acidic environment of the gut.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 123.76
Molecular weight 528.2
XLogP 3.07
No. Lipinski's rules broken 0
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Canonical SMILES O=C(c1cccc(n1)c1nc2c([nH]1)cccc2)N1CCN(CC1)C(=O)c1cccc(n1)c1nc2c([nH]1)cccc2
Isomeric SMILES O=C(c1cccc(n1)c1nc2c([nH]1)cccc2)N1CCN(CC1)C(=O)c1cccc(n1)c1nc2c([nH]1)cccc2
InChI InChI=1S/C30H24N8O2/c39-29(25-13-5-11-23(31-25)27-33-19-7-1-2-8-20(19)34-27)37-15-17-38(18-16-37)30(40)26-14-6-12-24(32-26)28-35-21-9-3-4-10-22(21)36-28/h1-14H,15-18H2,(H,33,34)(H,35,36)
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Summary of Clinical Use Click here for help
Phase 1 safety, tolerability and pharmacokinetics evaluations of BT-11 have been completed. Phase 2 studies in patients with either Crohn's disease or ulcerative colitis are registered with, but are not yet recruiting patients (as of April 2019). Click here to link to's full list of BT-11 trials.