GSK-2894512 | GSK2894512 [3
] | Vtama® | WB-1001 | WBI 1001 | WBI-1001
Tapinarof (GSK2894512) is an aryl hydrocarbon receptor (AhR) agonist [3
]. It is a naturally occurring polyphenol derived from bacteria that exist symbiotically with entomopathogenic nematodes. AhR was identified as the primary molecular target based on phenotypic screening using the DiscoveRx BioMAP Diversity Plus System and confirmed using AhR knockout mice. Tapinarof was the first steroid-free topical drug in this class to be approved as a plaque psoriasis medication.