cis-epoxysuccinic acid   Click here for help

GtoPdb Ligand ID: 9631

PDB Ligand
Compound class: Synthetic organic
Comment: Succinate receptor agonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 87.13
Molecular weight 132.01
XLogP -1.22
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES OC(=O)C1OC1C(=O)O
Isomeric SMILES OC(=O)[C@@H]1O[C@@H]1C(=O)O
InChI InChI=1S/C4H4O5/c5-3(6)1-2(9-1)4(7)8/h1-2H,(H,5,6)(H,7,8)/t1-,2+
InChI Key DCEMCPAKSGRHCN-XIXRPRMCSA-N
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
succinate receptor Hs Agonist Full agonist 5.6 – 5.8 pEC50 - 1-2
pEC50 5.8 (EC50 1.7x10-6 M) [2]
Description: IP3 accumulation, Emax=93%
pEC50 5.6 (EC50 2.7x10-6 M) [1]
Description: cAMP inhibition, Emax=100%