IL-34   

GtoPdb Ligand ID: 8975

Comment: IL-34 is an endogenous ligand of the receptor tyrosine kinase, colony stimulating factor 1 receptor (CSF1R) [3].
Species: Human
Bioactivity Comments
IL-34-induced increase in monocyte viability is inhibited by the CSF1R inhibitor GW-2580 [3]. IL-34 sustains inflammatory pathways in the gut [2] and has been associated with obesity, chronic inflammation, and insulin resistance [1].
Natural/Endogenous Targets
Target
colony stimulating factor 1 receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
colony stimulating factor 1 receptor Hs Agonist Agonist - - - 3
[3]