sarilumab   Click here for help

GtoPdb Ligand ID: 7999

Synonyms: Kevzara® | REGN88 | SAR153191
Approved drug Immunopharmacology Ligand
sarilumab is an approved drug (EMA & FDA (2017))
Compound class: Antibody
Comment: Sarilumab is a monoclonal antibody directed against the interleukin 6 receptor (IL6R).
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. Peptide sequence BLAST search using the heavy and light chain variable regions of sarilumab provides 100% matches to sequences covered by patent US7582298 [4], and to the antibody with designation VQ8F11-21.
Click here for help
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-6 receptor, α subunit Primary target of this compound Hs Antibody Binding 10.6 – 11.1 pKd - 4
pKd 10.6 – 11.1 (Kd 2.3x10-11 – 9x10-12 M) [4]
Description: Dissociation equilibrium constant calculated using two different assay methods (kinetic vs. equilibrium/solution)