ethopropazine   Click here for help

GtoPdb Ligand ID: 7181

Synonyms: Parsidol®
Approved drug
ethopropazine is an approved drug
Compound class: Synthetic organic
Comment: Ethopropazine is a phenothiazine derivative drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 31.78
Molecular weight 312.17
XLogP 5.25
No. Lipinski's rules broken 1
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Canonical SMILES CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC
Isomeric SMILES CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC
InChI InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3
Bioactivity Comments
We have been unable to find publicly available bioactivity data for this drug at its proposed molecular target to substantiate its MMOA, and have therefore not tagged a primary drug target.
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
M1 receptor Rn Antagonist Antagonist 8.5 pKi - 1
pKi 8.5 (Ki 3.1x10-9 M) [1]
Description: Displacement of [H]QNB binding in rat forebrain brain homogenate.
M2 receptor Rn Antagonist Antagonist 8.1 pKi - 1
pKi 8.1 (Ki 7.2x10-9 M) [1]
Description: Displacement of [H]QNB binding in rat hindbrain brain homogenate.