etaracizumab   Click here for help

GtoPdb Ligand ID: 6596

Synonyms: etaratuzumab | hLM60 | MEDI-522
Compound class: Antibody
Comment: Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
Click here for help
Bioactivity Comments
The affinity of the originating monoclonal, Vitaxin® (MEDI-523) was optimised by mutation of the Fc region (specifically isoleucine 332 of the CH2 domain) to generate etaracizumab (MEDI-522) [4], which expresses I332E mutation (Vitaxin-1M in the referenced patent). In the binding assays performed as part of the patent application Vitaxin® had a measured Kd of 3470nM.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
integrin αVβ3 Primary target of this compound Hs Antibody Binding 6.3 pKd - 4
pKd 6.3 (Kd 4.58x10-7 M) [4]