Compound class:
Endogenous peptide in human, mouse or rat
Species: Human
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Natural/Endogenous Targets | ||
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Targets where the ligand is described in the comment field | |
Target | Comment |
GPR39 | Zn2+ has been reported to be a potent and efficacious agonist of human, mouse and rat GPR39 [4]. Obestatin (GHRL, Q9UBU3), a fragment from the ghrelin precursor, was reported initially as an endogenous ligand, but subsequent studies failed to reproduce these findings. GPR39 has been reported to be down-regulated in adipose tissue in obesity-related diabetes [1]. Gene disruption results in obesity and altered adipocyte metabolism [3]. Reviewed in [2]. |