paroxetine   Click here for help

GtoPdb Ligand ID: 4790

Synonyms: paroxetine hydrochloride (anhydrous or hemihydrate) | Paxil® | Seroxat®
Approved drug PDB Ligand
paroxetine is an approved drug (FDA (1992))
Compound class: Synthetic organic
Comment: Paroxetine is a selective serotonin-reuptake inhibitor (SSRI) antidepressant. An X-ray structure of crystals of paroxetine bound SERT, shows a single central binding site [1] (see PDB entry 5I6X)..
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 39.72
Molecular weight 329.14
XLogP 3.32
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES Fc1ccc(cc1)C1CCNCC1COc1ccc2c(c1)OCO2
Isomeric SMILES Fc1ccc(cc1)[C@@H]1CCNC[C@H]1COc1ccc2c(c1)OCO2
InChI InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1
InChI Key AHOUBRCZNHFOSL-YOEHRIQHSA-N
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
P2X4 Hs Antagonist Antagonist 5.0 – 6.0 pIC50 - 2-3
pIC50 5.0 – 6.0 [2-3]
Selectivity at transporters
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
SERT Primary target of this compound Hs Inhibitor Inhibition 10.1 pKd - 1
pKd 10.1 (Kd 8x10-11 M) [1]
SERT Primary target of this compound Hs Inhibitor Inhibition 9.6 pKi - 4
pKi 9.6 (Ki 2.5x10-10 M) [4]