Synonyms: AMY-109 | H1009/L395-F1974m [2]
Compound class:
Antibody
Comment: AMY109 is a long-acting monoclonal antibody that blocks IL-8 recycling [4]. It was designed to reduce levels of IL-8 in endometriosis lesions, in which excessive IL-8 has been identified as a driving factor in promoting inflammation and fibrosis [1,3,5]. AMY109 is proposed as a potential disease-modifying treatment for endometriosis.
AMY109 is engineered to bind IL-8 in a pH-dependent manner. In the acidic conditions within the endosome, the antibody-IL-8 mmune complex dissociates; the free antibody is re-cycled and the IL-8 is trafficked to the lysosome for degradation. |
Bioactivity Comments |
AMY109 binds to cynoIL-8 with an affinity (Kd) of 0.38 nM (pKd 9.42) [4]. In vitro AMY109 inhibits both the recruitment of neutrophils to human endometriosis-derived cells, and neutrophil production of monocyte chemoattractant protein-1 [4]. |
Selectivity at ligand targets | ||||||||||||||||||||||||||||||||||
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