Z-AVLD-FMK   Click here for help

GtoPdb Ligand ID: 11712

Compound class: Peptide or derivative
Comment: Z-AVLD-FMK is a fluoromethylketone (FMK) modified 4 amino acid peptide, that has subnanomolar potency against SARS-CoV-2 3CL-like protease (Mpro) [1]. It is a peptidomimetic of the Mpro substrate sequence within the viral polyprotein.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Bioactivity Comments
Z-AVLD-FMK inhibits SARS-CoV-2 growth in Vero E6 cells with an EC50 of 66 μM [1].
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CoV 3C-like (main) protease SARS-CoV-2 Inhibitor Inhibition 9.1 pIC50 - 1
⤷ pIC50 9.1 (IC50 8x10-10 M) [1]
Description: Inhibition in a FRET-based enzyme activity assay