pitolisant   Click here for help

GtoPdb Ligand ID: 8924

Synonyms: BF2.649 | Ozawade® | tiprolisant [USAN] | Wakix®
Approved drug
pitolisant is an approved drug (EMA (2016), FDA (2019))
Compound class: Synthetic organic
Comment: Pitolisant is a selective antagonist/inverse agonist of the histamine H3 receptor [7-8,11].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 12.47
Molecular weight 295.17
XLogP 3.94
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc(cc1)CCCOCCCN1CCCCC1
Isomeric SMILES Clc1ccc(cc1)CCCOCCCN1CCCCC1
InChI InChI=1S/C17H26ClNO/c18-17-9-7-16(8-10-17)6-4-14-20-15-5-13-19-11-2-1-3-12-19/h7-10H,1-6,11-15H2
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA (2016), FDA (2019))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
8952 pitolisant
Synonyms Click here for help
BF2.649 | Ozawade® | tiprolisant [USAN] | Wakix®
Database Links Click here for help
Specialist databases
GPCRdb Ligand pitolisant
Other databases
CAS Registry No. 362665-56-3 (source: PubChem)
ChEMBL Ligand CHEMBL462605
DrugCentral Ligand 5048
GtoPdb PubChem SID 310264705
PubChem CID 9948102
Search Google for chemical match using the InChIKey NNACHAUCXXVJSP-UHFFFAOYSA-N
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UniChem Compound Search for chemical match using the InChIKey NNACHAUCXXVJSP-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey NNACHAUCXXVJSP-UHFFFAOYSA-N
Wikipedia Pitolisant