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arformoterol   Click here for help

GtoPdb Ligand ID: 7479

Synonyms: (-)-Formoterol | (R,R)-Formoterol | Brovana® | YM-08316
Approved drug PDB Ligand Immunopharmacology Ligand
arformoterol is an approved drug (FDA (2006))
Compound class: Synthetic organic
Comment: Arformoterol is the active (R,R)-enantiomer of formoterol. The marketed product contains arformoterol tartrate (PubChem CID 9827062).

arformoterol is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 9
Topological polar surface area 90.82
Molecular weight 344.17
XLogP 2.21
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O
Isomeric SMILES O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O
InChI InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)/t13-,19+/m1/s1
InChI Key BPZSYCZIITTYBL-YJYMSZOUSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (2006)
IUPAC Name Click here for help
N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide
Synonyms Click here for help
(-)-Formoterol | (R,R)-Formoterol | Brovana® | YM-08316
Database Links Click here for help
CAS Registry No. 67346-49-0
ChEBI CHEBI:408174
ChEMBL Ligand CHEMBL1363
DrugBank Ligand DB01274
DrugCentral Ligand 4943
GtoPdb PubChem SID 187051782
PubChem CID 3083544
RCSB PDB Ligand H98
Search Google for chemical match using the InChIKey BPZSYCZIITTYBL-YJYMSZOUSA-N
Search Google for chemicals with the same backbone BPZSYCZIITTYBL
UniChem Compound Search for chemical match using the InChIKey BPZSYCZIITTYBL-YJYMSZOUSA-N
UniChem Connectivity Search for chemical match using the InChIKey BPZSYCZIITTYBL-YJYMSZOUSA-N
Wikipedia Arformoterol

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MedChemExpress
Arformoterol (links to external site)
Cat. No. HY-B0010A