thalidomide

Ligand id: 7327

Name: thalidomide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 87.04
Molecular weight 258.06
XLogP 0.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1998), EMA (2008))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
2-(6-hydroxy-2-oxo-2,3,4,5-tetrahydropyridin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
International Nonproprietary Names
INN number INN
762 thalidomide
Synonyms
K-17
Comments
Thalidomide is principally an immunomodulatory drug. It inhibits synthesis of TNFα.
Database Links
CAS Registry No. 50-35-1
ChEMBL Ligand CHEMBL468
DrugBank Ligand DB01041
GtoPdb PubChem SID 178103899
Immunopaedia Search thalidomide
PubChem CID 5426
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Wikipedia Thalidomide

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Tocris
Thalidomide
Cat. No. 0652