ChEMBL ligand: CHEMBL468 (.alpha.-phthalimidoglutarimide, Celgene, Contergan, Distaval, K-17, Myrin, Neurosedyn, N-phthalylglutamic acid imide, NSC-527179, NSC-66847, Pantosediv, Pharmion, Softenon, Talidex, Thaled, Thalidomide, Thalidomide, Thalomid)
Cereblon isoform 4 in Magnetospirillum gryphiswaldense [ChEMBL: CHEMBL3763007] [UniProtKB: A4TVL0] There should be some charts here, you may need to enable JavaScript!
Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
Cyclooxygenase-2 in Sheep [ChEMBL: CHEMBL4102] [UniProtKB: P79208] There should be some charts here, you may need to enable JavaScript!
cereblon/Protein cereblon in Human [ChEMBL: CHEMBL3763008] [GtoPdb: 3086] [UniProtKB: Q96SW2] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Cereblon isoform 4 in Magnetospirillum gryphiswaldense (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3763007] [UniProtKB: A4TVL0]
ChEMBL	Inhibition of MANT-uracil binding to Magnetospirillum gryphiswaldense cereblon isoform 4 Y101F mutant by Cheng-Prusoff equation analysis	B	5.02	pKi	9600	nM	Ki	J Med Chem (2016) 59: 770-774 [PMID:26730808]
ChEMBL	Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by Cheng-Prusoff equation analysis	B	5.36	pKi	4400	nM	Ki	J Med Chem (2016) 59: 770-774 [PMID:26730808]
ChEMBL	Inhibition of MANT-uracil binding to wild-type Magnetospirillum gryphiswaldense CRBN isoform 4 by FRET assay	B	5.36	pKi	4400	nM	Ki	J Med Chem (2019) 62: 6615-6629 [PMID:31251063]
ChEMBL	Inhibition of MANT-uracil binding to Magnetospirillum gryphiswaldense cereblon isoform 4 Y101F mutant by FRET assay	B	4.97	pIC50	10700	nM	IC50	J Med Chem (2016) 59: 770-774 [PMID:26730808]
ChEMBL	Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by FRET assay	B	5.11	pIC50	7800	nM	IC50	J Med Chem (2016) 59: 770-774 [PMID:26730808]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibitory activity (RA1) against Prostaglandin G/H synthase 1 was calculated relative to aspirin	B	6.43	pIC50	370	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1043-1046 [PMID:11909713]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL	Inhibitory activity (RA2) against Prostaglandin G/H synthase 2 was calculated relative to aspirin	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1043-1046 [PMID:11909713]
cereblon/Protein cereblon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3763008] [GtoPdb: 3086] [UniProtKB: Q96SW2]
GtoPdb	Determined in a BiaCore assay using immobilised thalidomide and recombinant cereblon protein.	-	8.07	pKd	8.5	nM	Kd	Science (2010) 327: 1345-50 [PMID:20223979]
ChEMBL	Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by Cheng-Prusoff equation analysis	B	4.64	pKi	22700	nM	Ki	J Med Chem (2016) 59: 770-774 [PMID:26730808]
ChEMBL	Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence in presence of 0.5% DMSO by MST based assay	B	5.07	pKi	8510	nM	Ki	ACS Med Chem Lett (2021) 12: 74-81 [PMID:33488967]
ChEMBL	Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by FRET assay	B	4.52	pIC50	29900	nM	IC50	J Med Chem (2016) 59: 770-774 [PMID:26730808]
ChEMBL	Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence in presence of 0.5% DMSO by MST based assay	B	4.64	pIC50	22900	nM	IC50	ACS Med Chem Lett (2021) 12: 74-81 [PMID:33488967]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]