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ustekinumab   Click here for help

GtoPdb Ligand ID: 6885

Synonyms: CNTO-1275 | L04AC05 | Stelara® | TT-20
Approved drug Immunopharmacology Ligand
ustekinumab is an approved drug (FDA (2009), EMA (2009))
Compound class: Antibody
Comment: Ustekinumab suppresses the immunomodulatory actions of both IL-12 and IL-23 on T-cell sub-populations. It binds to the common p40 subunit (IL12B) shared by these cytokines.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Biosimilars:
NameTrade nameCompanyClinical PhaseIndications
ustekinumab-auub; ABP 654Wezlana; WezenlaAmgenApproved (2023 FDA, 2024 EMA)As per reference agent; Interchangeable with reference agent
ustekinumab-aekn; AVT04Selarsdi; UzpruvoAlvotech/Teva Pharmaceuticals/STADA ArzneimittelApproved (2024 FDA & EMA)As per reference agent
ustekinumab-ttwe; SB17Pyzchiva; Epyztek; EksunbiSandoz/Samsung BioepisApproved (2024 FDA, EMA and S Korea MFDS)As per reference agent; Interchangeable with reference agent*
ustekinumab; CT-P43SteQeymaCelltrionApproved (2024 EMA)As per reference agent
ustekinumab-aauz; FYB202Otulfi; Fymskina Fresenius Kabi/Formycon Approved (2024 EMA & FDA)As per reference agent; available as subcutaneous and intravenous formulations
ustekinumab-srlf; DMB-3115Imuldosa/AbsimkyAccord BioPharma/Intas PharmaceuticalsApproved (2024 EMA & FDA)As per reference agent
ustekinumab-kfce; Bmab1200Yesintek Biocon BiologicsApproved (2024 FDA, 2025 EMA)As per reference agent
ustekinumab-hmny; BAT2206StarjemzaBio-Thera Solutions/Hikma PharmaceuticalsApproved (2025 FDA)As per reference agent

*After expiry of the period of exclusivity for the first interchangeable biosimilar product.
Classification Click here for help
Compound class Antibody
Approved drug? Yes. EU EMA (2009)  |  US FDA (2009)
International Nonproprietary Names Click here for help
INN number INN
8954 ustekinumab
Synonyms Click here for help
CNTO-1275 | L04AC05 | Stelara® | TT-20
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 172
Other databases
GtoPdb PubChem SID 178103467
PubChem SID 178103467
Search PubMed clinical trials ustekinumab
Search PubMed titles ustekinumab
Search PubMed titles/abstracts ustekinumab
Wikipedia Ustekinumab