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ustekinumab   Click here for help

GtoPdb Ligand ID: 6885

Synonyms: CNTO-1275 | L04AC05 | Stelara® | TT-20
Approved drug Immunopharmacology Ligand
ustekinumab is an approved drug (FDA (2009), EMA (2009))
Compound class: Antibody
Comment: Ustekinumab suppresses the immunomodulatory actions of both IL-12 and IL-23 on T-cell sub-populations. It binds to the common p40 subunit (IL12B) shared by these cytokines.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Biosimilars:
NameTrade nameCompanyApprovalsIndications
ustekinumab-auub; ABP 654Wezlana; WezenlaAmgen2023 FDA, 2024 EMAAs per reference agent; Interchangeable with reference agent
ustekinumab-aekn; AVT04Selarsdi; Uzpruvo; UsgenaAlvotech/Teva Pharmaceuticals/STADA Arzneimittel2024 FDA & EMAAs per reference agent
ustekinumab-ttwe; SB17Pyzchiva; Epyztek; EksunbiSandoz/Samsung Bioepis2024 FDA, EMA and S. Korea MFDSAs per reference agent; Interchangeable with reference agent*
ustekinumab; CT-P43SteQeymaCelltrion2024 EMAAs per reference agent
ustekinumab-aauz; FYB202Otulfi; Fymskina Fresenius Kabi/Formycon 2024 EMA & FDAAs per reference agent; available as subcutaneous and intravenous formulations
ustekinumab-srlf; DMB-3115Imuldosa/AbsimkyAccord BioPharma/Intas Pharmaceuticals2024 EMA & FDAAs per reference agent
ustekinumab-kfce; Bmab1200Yesintek Biocon Biologics2024 FDA, 2025 EMAAs per reference agent
ustekinumab-hmny; BAT2206StarjemzaBio-Thera Solutions/Hikma Pharmaceuticals2025 FDAAs per reference agent
biosimilar ustekinumabUsrenty; YesintekBiosimilar Collaborations Ireland/Biocon Biologics2025 EMAAs per reference agent
biosimilar ustekinumabUsymroGedeon Richter2025 EMAAs per reference agent
biosimilar ustekinumabQoyvolmaCelltrion 2025 EMAAs per reference agent
biosimilar ustekinumabUsgenaStada Arzneimittel 2025 EMAAs per reference agent

*After expiry of the period of exclusivity for the first interchangeable biosimilar product.
Bioactivity Comments
The patent covering the production and use of ustekinumab (US6902734 [1]) does not provide affinity values for specific antibody clones, therefore we have included the stated range of affinities determined in the production and testing process in the interaction table below..
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-12B Primary target of this compound Hs Antibody Binding >9.6 – 11.1 pKd - 1,3
⤷ pKd >11.1 (Kd <7x10-12 M) [1]
pKd 9.6 (Kd 2.32x10-10 M) [3]