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IL-13   Click here for help

GtoPdb Ligand ID: 4980

Synonyms: hematopoietic growth factor | interleukin-13 | mast cell growth factor | multipotential colony-stimulating factor | P-cell-stimulating factor
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-13 shares sequence and structural homology with IL-4.
Species: Human
Natural/Endogenous Targets
Target
Interleukin-4 receptor type II
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-4 receptor type II Ligand is endogenous in the given species Hs Agonist Agonist - - -
⤷
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
abrezekimab Peptide Primary target of this compound Hs Antibody Binding 10.8 pKd - 3
⤷ pKd 10.8 (Kd 1.5x10-11 M) [3]
Description: In a BiaCore assay with immobilised antibody and recombinant hIL-13 as the analyte.
tralokinumab Peptide Approved drug Primary target of this compound Hs Antibody Binding 9.8 pKd - 6
⤷ pKd 9.8 (Kd 1.64x10-10 M) [6]
dectrekumab Peptide Primary target of this compound Hs Antibody Binding 9.3 pKd - 2
⤷ pKd 9.3 (Kd 4.8x10-10 M) [2]
Targets where the ligand is described in the comment field
Target Comment
Interleukin 13 receptor, α2 Decoy receptor that binds IL-13 (IL13, P35225) as a monomer.