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IFN-β   Click here for help

GtoPdb Ligand ID: 4967

Synonyms: Avonex® (recombinant IFN-beta-1a) | fibroblast interferon | interferon beta
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IFN-β is a type I IFN. The peptide sequence of the clinically used recombinant protein IFN-beta-1a is identical to that of the endogenous peptide.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Natural/Endogenous Targets
Target
Interferon-α/β receptor
interferon α/β receptor 1
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
interferon α/β receptor 1 Ligand is endogenous in the given species Hs Agonist Agonist 7.8 pKd - 2
⤷ pKd 7.8 (Kd 1.58x10-8 M) [2]
Description: Measured using a surface plasmon resonance (SPR) assay, and recombinant hIFNAR1-extracellular domain (ECD) expressed in insect cells.
Interferon-α/β receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -
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Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
dazukibart Peptide Hs Antibody Binding 10.4 pKd - 1
⤷ pKd 10.4 (Kd 3.6x10-11 M) [1]
Description: Binding affinity of antibody CTI-AF1 for hIFNβ determined by SPR