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hepatocyte growth factor   Click here for help

GtoPdb Ligand ID: 4949

Abbreviated name: HGF
Synonyms: hepapoietin A | scatter factor (SF)
Compound class: Endogenous peptide in human, mouse or rat
Comment: The active peptide is a heterodimer comprising an alpha chain and a beta chain that are cleaved from the same precursor polypeptide. The subunits are linked by a disulphide bond.
Species: Human
Natural/Endogenous Targets
Target
MET proto-oncogene, receptor tyrosine kinase
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
MET proto-oncogene, receptor tyrosine kinase Ligand is endogenous in the given species Hs None - - - -
⤷
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
rilotumumab Peptide Primary target of this compound Hs Antibody Binding 9.7 – 10.3 pKd - 1
⤷ pKd 9.7 – 10.3 (Kd 2.2x10-10 – 5.4x10-11 M) [1]
Description: Dissociation equilibrium constant calculated using two different assay methods (kinetic vs. equilibrium/solution)