phenylacetylrinvanil   Click here for help

GtoPdb Ligand ID: 4283

Synonyms: 12-Phenylacetyl-ricinoleoyl-vanillamide [1] | compound 1e [PMID: 15356216] | IDN5890 | PhAR
Compound class: Synthetic organic
Comment: Phenylacetylrinvanil is a 'capsaicinoid' type compound that is a potent agonist/activator at the transient receptor potential vanilloid type 1 (TRPV1) channel [2]. Structurally it is a hybrid molecule that combines a vanillamide TRPV1 agonist with a non-polyunsaturated fatty acid-derived cannabinoid CB2 receptor-selective ligand. Phenylacetylrinvanil has demonstrated some antineoplastic activity against leukaemia cells in vitro and in vivo [3] and against cervical cancer tumour cell lines [4].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 23
Topological polar surface area 84.86
Molecular weight 551.36
XLogP 9.12
No. Lipinski's rules broken 2
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Canonical SMILES CCCCCCC(OC(=O)Cc1ccccc1)CC=CCCCCCCCC(=O)NCc1ccc(c(c1)OC)O
Isomeric SMILES CCCCCC[C@@H](OC(=O)Cc1ccccc1)C/C=C/CCCCCCCC(=O)NCc1ccc(c(c1)OC)O
InChI InChI=1S/C34H49NO5/c1-3-4-5-15-20-30(40-34(38)26-28-18-13-12-14-19-28)21-16-10-8-6-7-9-11-17-22-33(37)35-27-29-23-24-31(36)32(25-29)39-2/h10,12-14,16,18-19,23-25,30,36H,3-9,11,15,17,20-22,26-27H2,1-2H3,(H,35,37)/b16-10+/t30-/m1/s1
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
(7R,9E)-17-{[(4-hydroxy-3-methoxyphenyl)methyl]carbamoyl}heptadec-9-en-7-yl 2-phenylacetate
Synonyms Click here for help
12-Phenylacetyl-ricinoleoyl-vanillamide [1] | compound 1e [PMID: 15356216] | IDN5890 | PhAR
Database Links Click here for help
Specialist databases
GPCRdb Ligand phenylacetylrinvanil
Other databases
BindingDB Ligand 86536
GtoPdb PubChem SID 178101100
PubChem CID 57340639
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